GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin

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GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin.

UNLABELLED Melatonin supplementation has been used as a therapeutic agent for several diseases, yet little is known about the underlying mechanisms by which melatonin synchronizes circadian rhythms. G-protein signaling plays a large role in melatonin-induced phase shifts of locomotor behavior and melatonin receptors activate G-protein-coupled inwardly rectifying potassium (GIRK) channels in Xen...

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Orexins (hypocretins) are recently discovered excitatory transmitters implicated in arousal and sleep. Yet, their ionic and signal transduction mechanisms have not been fully clarified. Here we show that orexins suppress GIRK channel activity, and this suppression is likely to lead to neuronal excitation. Cultured neurons from the locus coeruleus (LC) and the nucleus tuberomammillaris (TM) were...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2015

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.1597-15.2015